The Roots of Chronic Disease

Expanded Opal Science

The mechanisms that underlie chronic disease - autophagy/mTOR, NADPH production, Nrf2 and antioxidant function, etc. - are under genetic control, and getting to the roots of disease requires a knowledge of each patient’s unique genetic make-up for these underlying mechanisms.

Expanded Opal Science
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At the heart of Opal lies this map of mechanisms, and the pathways and corresponding genetics of each user will be available within Opal to guide doctors with personalized treatment on a deep level.

The map also contains known natural interventions that will allow doctors to make the deep changes necessary for difficult patients to improve - or for wellness patients to feel even better - naturally.

Source: NutriGenetic Research


We need nutrients to build tissue, create signaling molecules, neurotransmitters and much more. But at the root of nutritional medicine is something bigger.

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Underlying genes for “disposition” towards chronic conditions lies another group of genes. These are what Opal considers the Foundational Mechanisms*. These are the mechanisms that must function properly to attain optimal health and longevity.

If these pathways can be modulated properly, the foundations of health and longevity will be in place to build future health upon. The good thing is if the dysregulation of these mechanisms is acquired, which it is in most cases, then they can often be returned to function – through nutritional factors.

*These mechanisms are inflammatory pathways - autophagy/mtor, oxidative stress response, NAD pathways, heme pathways and detox pathways.


Our bodies are finely attuned to protection. This protective response is triggered by any toxin, invasion, or stressor. Nutrients and metabolites are the mainstays of this response.

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To successfully resolve the threat response our system must be able to clear not only the invader but also the response.

Systems that are nutritionally deficient are impaired in returning to homeostasis and this can perpetuate the response, leading to a chronic response and eventually chronic disease.

Cell Danger Response (CDR)

The cell danger response is a security system that tells your body to close ranks in order to isolate & process out an invader. An invader is any material that is not among the naturally-occurring substances that comprise a human body.

When the CDR system succeeds, your body eliminates the invader; if your body fails to neutralize the threat, the residue may be inflammation, a damaged immune response, free radical damage & incorrectly-folded proteins-all of which can result in cell damage or death, short cell turnover cycles, heightened telomere shortening, exacerbated aging & chronic disease.